CAS No. 2446928-30-7

Batch: Purity:97.56
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BMS-986365 Chemical Structure
Chemical Structure
Check the BMS-986365 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[(2R)-4-[2-[4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl]-2-ethylphenoxy]ethyl]-2-methylpiperazin-1-yl]-N-[3-[(2,6-dioxopiperidin-3-yl)amino]phenyl]acetamide
CAS Number 2446928-30-7
Molecular Formula

C41H45F3N8O5S
Molecular Weight (MW) 818.91
InChIKey YUVGVJYLOFTILT-NHYGQJMQSA-N

Ordering Information

Biological Activity

BMS-98665 is a heterobifunctional ligand-directed degrader and antagonist targeting the androgen receptor (AR). By engaging cereblon and the AR ligand-binding domain, it recruits the CRL-CRBN Eligase complex to drive the targeted ubiquitination and degradation of wild-type and mutant AR proteins across cytoplasmic and nuclear compartments. This dual mechanism suppresses downstream AR signaling, inhibits androgen-driven target gene transcription, and blocks prostate cancer cell proliferation and tumor growth. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (122.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 6 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.