CAS No. 2001559-19-7
Batch:
Purity:99.85
Chemical Structure
Check the
BMS-986260
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-[5-(3-chloro-4-fluorophenyl)-3-(2-hydroxyethyl)imidazol-4-yl]imidazo[1,2-b]pyridazine-3-carbonitrile | |
|---|---|---|
| CAS Number | 2001559-19-7 | |
| Molecular Formula |
C18H12ClFN6O |
|
| Molecular Weight (MW) | 382.78 | |
| InChIKey | VZZBCNXVZFAIQX-UHFFFAOYSA-N |
BMS-986260 is an orally active immuno-oncology agent that functions as a potent inhibitor of TGFβR1. By inhibiting TGFβR1 kinase activity, BMS-986260 blocks downstream TGFβ signaling pathways and impairs TGFβ-induced SMAD2/3 phosphorylation and nuclear translocation. This inhibition disrupts TGFβ-mediated immunosuppressive and fibrotic pathways, suppressing downstream target gene activation and cellular phenotypic responses in tumor and stromal microenvironments. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
77 mg/mL
(201.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 19 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.