CAS No. 1815613-42-3
Batch:
Purity:99.03
Chemical Structure
Check the
BMS-986176
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-1-[[2-(difluoromethyl)-6-[2-(difluoromethyl)-4-pyridinyl]-3-pyridinyl]oxy]-2,4-dimethylpentan-2-amine | |
|---|---|---|
| CAS Number | 1815613-42-3 | |
| Molecular Formula |
C19H23F4N3O |
|
| Molecular Weight (MW) | 385.40 | |
| InChIKey | RKAHOQATMSONTM-IBGZPJMESA-N |
BMS-986176 is a highly selective, brain-penetrant, potent inhibitor of adaptor protein-2 associated kinase 1 (AAK1). Inhibition of AAK1 modulates clathrin-mediated endocytosis and receptor trafficking pathways in central nervous system neurons. Disruption of these endocytic signaling pathways decreases pathological neuronal sensitization and central pain transmission, ultimately attenuating nociceptive behaviors and neuropathic pain phenotypes in preclinical rodent models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
77 mg/mL
(199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 77 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.