CAS No. 1231889-53-4

Batch: Purity:99.98
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BMS-935177 Chemical Structure
Chemical Structure
Check the BMS-935177 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 7-(2-hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxoquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide
CAS Number 1231889-53-4
Molecular Formula

C31H26N4O3
Molecular Weight (MW) 502.56
SMILES CC1=C(C=CC=C1N2C=NC3=CC=CC=C3C2=O)C4=C5C6=C(C=C(C=C6)C(C)(C)O)NC5=C(C=C4)C(=O)N
InChIKey TVJRDCQUZMGBAB-UHFFFAOYSA-N

Ordering Information

Biological Activity

BMS-935177 is a potent, reversible Bruton's tyrosine kinase (BTK) inhibitor that exhibits pronounced selectivity against other Tec family kinases. By suppressing BTK activity, this compound effectively blocks B-cell receptor signaling and modulates downstream pathways, including NF-kB and AKT/mTOR. This inhibition leads to reduced B-cell proliferation and decreased cellular survival, highlighting its utility for investigating BTK-mediated signaling cascades. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (198.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.