CAS No. 1000998-59-3
Batch:
Purity:98.93
Chemical Structure
Check the
BMS-687453
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1000998-59-3 | |
|---|---|---|
| Molecular Formula |
C22H21ClN2O6 |
|
| Molecular Weight (MW) | 444.86 | |
| SMILES | CC1=C(N=C(O1)C2=CC=C(C=C2)Cl)COC3=CC=CC(=C3)CN(CC(=O)O)C(=O)OC |
BMS-687453 is a potent and selective agonist targeting peroxisome proliferator-activated receptor alpha (PPARα). Activation of PPARα regulates downstream signaling pathways involved in fatty acid oxidation, lipid transport, and energy homeostasis. Consequently, PPARα stimulation leads to reduced cellular lipid accumulation and modulation of metabolic transcriptional programs involved in dyslipidemia and inflammatory processes. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
89 mg/mL
(200.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 89 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.