CAS No. 2407854-18-4
Batch:
Purity:99.49
Chemical Structure
Check the
BMS-502
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 8-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-5-methyl-7-nitro-6-oxo-1,5-naphthyridine-2-carbonitrile | |
|---|---|---|
| CAS Number | 2407854-18-4 | |
| Molecular Formula |
C27H22F2N6O3 |
|
| Molecular Weight (MW) | 516.50 | |
| InChIKey | XAHMIJCNFUSTMT-UHFFFAOYSA-N |
Biological Activity
BMS-2 is a dual small-molecule inhibitor of diacylglycerol kinase (DGK) α and DGK ζ (IC. By blocking DGK-mediated conversion of diacylglycerol to phosphatidic acid, it enhances intracellular signaling cascades downstream of the T-cell receptor. This blockade restores T-cell activation, increases interferon-γ release, and promotes T-cell proliferation to enhance antitumor immune responses. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
25 mg/mL
(48.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.