CAS No. 547757-23-3
Batch:
Purity:99.19
Chemical Structure
Check the
BMS-345541 hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N'-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine;hydrochloride | |
|---|---|---|
| CAS Number | 547757-23-3 | |
| Molecular Formula |
C14H17N5.ClH |
|
| Molecular Weight (MW) | 291.78 | |
| InChIKey | MIDKPVLYXNLFGZ-UHFFFAOYSA-N |
BMS-345541 hydrochloride is a selective inhibitor of IKK-2 (IC50 of 0.3 μM) and IKK-1 (IC50 of 4 μM) that binds to an allosteric subunit site on the kinase complex. By inhibiting catalytic activity, BMS-345541 blocks IκBα phosphorylation and degradation, thereby preventing NF-kB nuclear translocation and inhibiting downstream inflammatory cytokine transcription and gene expression. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
58 mg/mL
(198.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 58 mg/mL |
| Ethanol | 4 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.