CAS No. 2101517-69-3
| IUPAC Name | (2R)-2-[[3,5-bis(trifluoromethyl)phenyl]carbamothioylamino]-N-(2,4-difluorophenyl)-2-phenylacetamide | |
|---|---|---|
| CAS Number | 2101517-69-3 | |
| Molecular Formula |
C23H15F8N3OS |
|
| Molecular Weight (MW) | 533.44 | |
| SMILES | C1=CC=C(C=C1)C(C(=O)NC2=C(C=C(C=C2)F)F)NC(=S)NC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F | |
| InChIKey | BDBWQANRZRCMMD-LJQANCHMSA-N |
BL-918 is a potent, orally active activator of UNC-51-like kinase 1 (ULK1). Activation of ULK1 stimulates autophagy initiation by engaging downstream complexes including Beclin-1 and VPS34, thereby enhancing cellular autophagic flux. Through upregulation of this cytoprotective autophagic pathway, BL-918 promotes clearance of toxic cellular aggregates and preserves neuronal cell viability, offering potential neuroprotective utility in models of Parkinson's disease. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(187.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(187.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(187.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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