CAS No. 1392399-03-9
Batch:
Purity:100.00
Chemical Structure
Check the
BIX-01294 Trihydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine;trihydrochloride | |
|---|---|---|
| CAS Number | 1392399-03-9 | |
| Molecular Formula |
C28H38N6O2.3HCl |
|
| Molecular Weight (MW) | 600.02 | |
| SMILES | CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC.Cl.Cl.Cl | |
| InChIKey | FMURUEPQXKJIPS-UHFFFAOYSA-N |
BIX-01294 trihydrochloride is a selective inhibitor of G9a histone methyltransferase in a cell-free assay) and weakly inhibits G9a-like protein (GLP). By blocking G9a activity, it reduces histone H3 lysine 9 dimethylation (H3K9me2) in bulk histones without significant activity against other histone methyltransferases, leading to altered gene expression and downstream induction of autophagy. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
98 mg/mL
(163.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 98 mg/mL |
| Ethanol | 8 mg/mL |
| DMSO |
100 mg/mL
(166.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
| DMSO |
100 mg/mL
(166.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 25 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- BIX-01294 Trihydrochloride Solubility in DMSO
- BIX-01294 Trihydrochloride Stock Solution
- BIX-01294 Trihydrochloride Storage
- BIX-01294 Trihydrochloride Stability
- BIX-01294 Trihydrochloride Molecular Weight
- BIX-01294 Trihydrochloride SMILES
- BIX-01294 Trihydrochloride Chemical Structure (2D and 3D)
- BIX-01294 Trihydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.