CAS No. 4246-51-9
Batch:
Purity:99
Chemical Structure
Check the
Bis-NH2-C1-PEG3
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 4246-51-9 | |
|---|---|---|
| Molecular Formula |
C10H24N2O3 |
|
| Molecular Weight (MW) | 220.31 | |
| SMILES | C(CN)COCCOCCOCCCN |
Bis-NH2-C1-PEG3 is a PEG-based PROTAC linker utilized in the synthesis of proteolysis targeting chimeras (PROTACs). By joining a target protein-binding ligand with an E3 ubiquitin ligase ligand, PEG-based linkers facilitate the recruitment of target proteins to E3 ligase complexes. This promotes target protein polyubiquitination and subsequent degradation via the ubiquitin-proteasome system, modulating downstream cellular signal transduction pathways. [1][2]
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Concentration
Volume
Mass
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1 mg | 5 mg | 10 mg |
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
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Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.