CAS No. 159997-94-1
Batch:
Purity:99.77
Chemical Structure
Check the
Biricodar
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 159997-94-1 | |
|---|---|---|
| Molecular Formula |
C34H41N3O7 |
|
| Molecular Weight (MW) | 603.71 |
Biological Activity
Biricodar (VX-710) is a modulator and inhibitor of ATP-binding cassette (ABC) efflux transporters, including P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP-1), and breast cancer resistance protein (BCRP). By blocking efflux transport, it increases intracellular drug accumulation and restores chemosensitivity in multidrug-resistant tumor cells. Additionally, Biricodar inhibits bacterial efflux pumps, enhancing the effectiveness of fluoroquinolones and other antibiotics against Gram-positive pathogens.[1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(165.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(165.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.