CAS No. 1623-93-4

Batch: Purity:98
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Biphenyl-4-sulfonyl chloride Chemical Structure
Chemical Structure
Check the Biphenyl-4-sulfonyl chloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-phenylbenzenesulfonyl chloride
CAS Number 1623-93-4
Molecular Formula

C12H9ClO2S
Molecular Weight (MW) 252.72
SMILES C1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)Cl
InChIKey ALBQXDHCMLLQMB-UHFFFAOYSA-N

Biological Activity

Biphenyl-4-sulfonyl chloride is a histone deacetylase (HDAC) inhibitor that also serves as a versatile reagent in synthetic chemistry. By targeting HDAC enzymes, HDAC inhibitors modulate the HDAC pathway by preventing the removal of acetyl groups from lysine residues on histones. This activity promotes chromatin remodeling, which regulates gene transcription to induce cell cycle arrest and cell death. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (197.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Richon VM, et al. Proc Natl Acad Sci U S A. 1998;95(6):3003-7.

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Note: Technical data last updated: Sep 1, 2026.