CAS No. 101714-41-4

Batch: Purity:99.93
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BiP Inducer X (BIX) Chemical Structure
Chemical Structure
Check the BiP Inducer X (BIX) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [2-(3,4-dihydroxyphenyl)-2-oxoethyl] thiocyanate
CAS Number 101714-41-4
Molecular Formula

C9H7NO3S
Molecular Weight (MW) 209.22
SMILES OC1=C(O)C=C(C=C1)C(=O)CSC#N
InChIKey SVFLBLCWKKQKDW-UHFFFAOYSA-N

Biological Activity

BiP Inducer X (BIX) is a selective molecular chaperone inducer that preferentially targets immunoglobulin heavy-chain binding protein (BiP/GRP78). It activates endoplasmic reticulum stress response elements upstream of the BiP gene through the ATF6 pathway. This selective upregulation of BiP attenuates ER stress–induced apoptosis and protects neurons from cell death in cerebral ischemia. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 42 mg/mL (200.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 42 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Kudo T, et al. Cell Death Differ. 2008;15(2):364-375.

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Note: Technical data last updated: Sep 1, 2026.