CAS No. 188011-69-0
Batch:
Purity:99.97
Chemical Structure
Check the
Bikinin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-[(5-bromo-2-pyridinyl)amino]-4-oxobutanoic acid | |
|---|---|---|
| CAS Number | 188011-69-0 | |
| Molecular Formula |
C9H9BrN2O3 |
|
| Molecular Weight (MW) | 273.08 | |
| SMILES | C1=CC(=NC=C1Br)NC(=O)CCC(=O)O | |
| InChIKey | XFYYQDHEDOXWGA-UHFFFAOYSA-N |
Biological Activity
Bikinin is an ATP-competitive plant GSK-3 kinase inhibitor that directly targets brassinosteroid-insensitive 2 (BIN2) alongside related GSK-3/SHAGGY-like kinases. By inhibiting BIN2 activity, bikinin prevents the phosphorylation and subsequent inactivation of key transcription factors, thereby stimulating downstream brassinosteroid signaling. This pathway activation drives plant cell expansion, tissue elongation, and phenotypic responses characteristic of brassinosteroid stimulation. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
54 mg/mL
(197.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.