CAS No. 2770960-52-4

Batch: Purity:99.54
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BIIB129 Chemical Structure
Chemical Structure
Check the BIIB129 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-methyl-N-[3-methyl-3-[6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxycyclobutyl]prop-2-enamide
CAS Number 2770960-52-4
Molecular Formula

C19H22N6O2
Molecular Weight (MW) 366.42
InChIKey WBFSPPPOPIJCLF-UHFFFAOYSA-N

Biological Activity

BIIB129 is a brain-penetrant covalent inhibitor of Bruton's tyrosine kinase (BTK) featuring high kinome selectivity. By inhibiting BTK within the B-cell receptor signaling pathway, it suppresses activation, signaling cascades, and central nervous system B-cell proliferation. Consequently, this targeted action attenuates neuroinflammatory processes, highlighting its potential utility as an immunomodulatory agent for multiple sclerosis. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 73 mg/mL (199.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 18 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Honigberg LA, et al. Proc Natl Acad Sci U S A. 2010;107(29):13075-80.

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Note: Technical data last updated: Sep 1, 2026.