CAS No. 1611493-60-7
Batch:
Purity:99.93
Chemical Structure
Check the
Bictegravir
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1611493-60-7 | |
|---|---|---|
| Molecular Formula |
C21H18F3N3O5 |
|
| Molecular Weight (MW) | 449.38 | |
| SMILES | C1CC2CC1N3C(O2)CN4C=C(C(=O)C(=C4C3=O)O)C(=O)NCC5=C(C=C(C=C5F)F)F |
Bictegravir (GS-9883) is a potent inhibitor of HIV-1 integrase that targets the catalytic site of the enzyme. By specifically inhibiting the strand transfer step during viral DNA integration into the host chromosome, Bictegravir prevents the stable insertion of proviral DNA. This inhibition blocks subsequent viral transcription and replication, resulting in potent suppression of viral propagation in HIV-1 infected cells. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
90 mg/mL
(200.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
90 mg/mL
(200.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 90 mg/mL |
| Water | Insoluble |
| DMSO |
90 mg/mL
(200.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 45 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.