CAS No. 1807988-02-8
Batch:
Purity:99.77
Chemical Structure
Check the
Bictegravir Sodium
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | sodium (1S,11R,13R)-3,6-dioxo-7-[(2,4,6-trifluorophenyl)methylcarbamoyl]-12-oxa-2,9-diazatetracyclo[11.2.1.02,11.04,9]hexadeca-4,7-dien-5-olate | |
|---|---|---|
| CAS Number | 1807988-02-8 | |
| Molecular Formula |
C21H18F3N3O5.Na |
|
| Molecular Weight (MW) | 473.38 | |
| SMILES | [NaH].OC1=C2N(CC3OC4CCC(C4)N3C2=O)C=C(C(=O)NCC5=C(F)C=C(F)C=C5F)C1=O | |
| InChIKey | WJNFBIVCQMPPJC-FQYDJHLKSA-M |
Bictegravir Sodium is a novel, potent small-molecule inhibitor of HIV-1 integrase, specifically targeting integrase strand transfer activity with an IC50 of 7.5 nM. By blocking the viral DNA integration step into the host genome, it effectively disrupts the HIV-1 replication cycle, leading to robust inhibition of viral propagation in T-cell lines and primary human T lymphocytes. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
2 mg/mL
(4.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.