CAS No. 191868-14-1

Batch: Purity:99.75
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BIBO 3304 Trifluoroacetate Chemical Structure
Chemical Structure
Check the BIBO 3304 Trifluoroacetate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2R)-N-[[4-[(carbamoylamino)methyl]phenyl]methyl]-5-(diaminomethylideneamino)-2-[(2,2-diphenylacetyl)amino]pentanamide;2,2,2-trifluoroacetic acid
CAS Number 191868-14-1
Molecular Formula

C31H36F3N7O5
Molecular Weight (MW) 643.66
SMILES NC(=N)NCCCC(NC(=O)C(C1=CC=CC=C1)C2=CC=CC=C2)C(=O)NCC3=CC=C(CNC(N)=O)C=C3.OC(=O)C(F)(F)F
InChIKey FBMCYYWIBYEOST-GJFSDDNBSA-N

Ordering Information

Biological Activity

BIBO 3304 Trifluoroacetate is a neuropeptide Y Y1 receptor (NPY1R) antagonist that selectively inhibits the human Y1 receptor (IC50 0.38 nM) and rat Y1 receptor (IC50 0.72 nM) over human Y2, Y4, and Y5 receptors (IC50 > 1000 nM). By blocking NPY1R signaling, it suppresses downstream NPY-mediated signaling pathways, resulting in the inhibition of NPY- and fasting-induced food intake in rodents. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (155.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.