CAS No. 960293-88-3
Batch:
Purity:96.63
Chemical Structure
Check the
BI605906
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3-amino-4-(1,1-difluoropropyl)-6-(4-methylsulfonylpiperidin-1-yl)thieno[2,3-b]pyridine-2-carboxamide | |
|---|---|---|
| CAS Number | 960293-88-3 | |
| Molecular Formula |
C17H22F2N4O3S2 |
|
| Molecular Weight (MW) | 432.51 | |
| InChIKey | IYHHRZBKXXKDDY-UHFFFAOYSA-N |
Biological Activity
BI605906 is a selective inhibitor of IκB kinase β (IKKβ) that regulates canonical NF-κB pathway signaling. By suppressing the phosphorylation and activation of IKKβ, BI605906 blocks cytokine-induced IκB degradation and downstream inflammatory signaling. Consequently, IKKβ inhibition reduces the expression of proinflammatory cytokines and impairs Toll-like receptor-mediated type 1 interferon production in dendritic cells.[1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
86 mg/mL
(198.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.