CAS No. 1883429-22-8
Batch:
Purity:99.67
Chemical Structure
Check the
BI-9564
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[4-[(dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1-one | |
|---|---|---|
| CAS Number | 1883429-22-8 | |
| Molecular Formula |
C20H23N3O3 |
|
| Molecular Weight (MW) | 353.41 | |
| SMILES | CN1C=C(C2=C(C1=O)C=NC=C2)C3=C(C=C(C(=C3)OC)CN(C)C)OC | |
| InChIKey | BJFSUDWKXGMUKA-UHFFFAOYSA-N |
BI-9564 is a selective inhibitor of BRD9 and BRD7. By targeting the bromodomains of BRD9 and BRD7, it selectively disrupts the SWI/SNF chromatin remodeling complex pathway. This inhibition leads to downregulated gene transcription and suppressed cell proliferation in acute myeloid leukemia and other cancer models, demonstrating potent anti-tumor activity in preclinical studies. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 16 mg/mL |
| DMSO |
3 mg/mL
(8.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | 7 mg/mL |
| DMSO |
6 mg/mL
(16.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | 26 mg/mL |
| DMSO |
18 mg/mL
(50.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.