CAS No. 1207293-36-4
| IUPAC Name | 3-[3-[N-[4-[(dimethylamino)methyl]phenyl]-C-phenylcarbonimidoyl]-2-hydroxy-1H-indol-6-yl]-N-ethylprop-2-ynamide | |
|---|---|---|
| CAS Number | 1207293-36-4 | |
| Molecular Formula |
C29H28N4O2 |
|
| Molecular Weight (MW) | 464.56 | |
| SMILES | CCNC(=O)C#CC1=CC2=C(C=C1)C(=C(N2)O)C(=NC3=CC=C(C=C3)CN(C)C)C4=CC=CC=C4 | |
| InChIKey | OCUQMWSIGPQEMX-UHFFFAOYSA-N |
BI-847325 is an orally bioavailable dual inhibitor of MEK and Aurora kinases, targeting human MEK1, MEK2, Aurora A, Aurora C, and Xenopus laevis Aurora B. Blockade of MEK suppresses the downstream RAF/MEK/ERK signaling pathway to reduce cell proliferation, while inhibition of Aurora kinases impairs mitotic spindle assembly and chromosome alignment during mitosis. Dual targeting of these pathways disrupts cancer cell cycle progression and promotes apoptotic cell death. [1]
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Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
19 mg/mL
(40.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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