CAS No. 1189767-28-9
Batch:
Purity:99.91
Chemical Structure
Check the
BI-409306
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-(oxan-4-yl)-6-(pyridin-2-ylmethyl)-5H-pyrazolo[5,4-d]pyrimidin-4-one | |
|---|---|---|
| CAS Number | 1189767-28-9 | |
| Molecular Formula |
C16H17N5O2 |
|
| Molecular Weight (MW) | 311.34 | |
| SMILES | C1COCCC1N2C3=C(C=N2)C(=O)NC(=N3)CC4=CC=CC=N4 | |
| InChIKey | BZTIJCSHNVZMES-UHFFFAOYSA-N |
BI-409306 is a potent and selective phosphodiesterase 9A (PDE9A) inhibitor. By selectively inhibiting PDE9A, it prevents cyclic guanosine monophosphate (cGMP) degradation, leading to elevated intracellular cGMP levels in brain tissue. This activation of cGMP-mediated signaling promotes synaptic plasticity, including long-term potentiation, and enhances cognitive function, specifically improving episodic and working memory performance in rodent models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
62 mg/mL
(199.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | ˂1 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.