CAS No. 2166387-65-9
Batch:
Purity:99.72
Chemical Structure
Check the
BI-3802
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[6-[[5-chloro-2-[(3S,5R)-3,5-dimethylpiperidin-1-yl]pyrimidin-4-yl]amino]-1-methyl-2-oxoquinolin-3-yl]oxy-N-methylacetamide | |
|---|---|---|
| CAS Number | 2166387-65-9 | |
| Molecular Formula |
C24H29ClN6O3 |
|
| Molecular Weight (MW) | 484.98 | |
| SMILES | CNC(=O)COC1=CC2=C(C=CC(=C2)NC3=NC(=NC=C3Cl)N4CC(C)CC(C)C4)N(C)C1=O | |
| InChIKey | GXTJETQFYHZHNB-GASCZTMLSA-N |
BI-3802 is a potent degrader of the oncogenic transcription factor BCL6, targeting the BCL6 BTB domain (IC50 ≤ 3 nM). BI-3802 induces cellular BCL6 polymerization and ubiquitin-dependent proteasomal degradation. This results in the strong de-repression of downstream BCL6 target genes, suppressing BCL6-driven transcriptional repression and exhibiting robust antiproliferative and antitumor activity in lymphoma models.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
3 mg/mL
(6.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
3 mg/mL
(6.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.