CAS No. 2937344-16-4

Batch: Purity:99.70
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BI-2493 Chemical Structure
Chemical Structure
Check the BI-2493 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (7S)-2'-amino-3-[2-[(2S)-2-methylpiperazin-1-yl]pyrimidin-4-yl]spiro[5,6-dihydro-4H-1,2-benzoxazole-7,4'-6,7-dihydro-5H-1-benzothiophene]-3'-carbonitrile
CAS Number 2937344-16-4
Molecular Formula

C24H27N7OS
Molecular Weight (MW) 461.58
InChIKey PVOYBVVIBNPTPJ-BSEYFRJRSA-N

Biological Activity

BI-is a structural analogue of BI-that functions as a highly selective pan-KRAS inhibitor. It selectively targets the GDP-bound inactive OFF state of KRAS, suppressing downstream signaling through the RAF/MEK/ERK pathway. By blocking oncogenic KRAS signaling across multiple mutant alleles and wild-type amplified tumor models, BI-2493 inhibits cancer cell proliferation and significantly attenuates tumor growth in vivo. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 92 mg/mL (199.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Kim D, et al. Nature. 2023;619(7968):160-166.

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Note: Technical data last updated: Sep 1, 2026.