CAS No. 2163056-91-3

Batch: Purity:99.77
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BI-1347 Chemical Structure
Chemical Structure
Check the BI-1347 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[4-(4-isoquinolin-4-ylphenyl)pyrazol-1-yl]-N,N-dimethylacetamide
CAS Number 2163056-91-3
Molecular Formula

C22H20N4O

 
Molecular Weight (MW) 356.42
SMILES CN(C)C(=O)CN1C=C(C=N1)C2=CC=C(C=C2)C3=CN=CC4=CC=CC=C43
InChIKey WULUGQONDYDNKY-UHFFFAOYSA-N

Ordering Information

Biological Activity

BI-1347 is a potent small-molecule inhibitor of cyclin-dependent kinase 8 (CDK8). As a key enzymatic component of the Mediator complex, CDK8 regulates transcriptional machinery and promotes oncogenic Wnt/beta-catenin pathway signaling. By targeting CDK8 activity, this compound modulates Mediator-dependent gene transcription, leading to down-regulation of downstream proliferative target genes and suppression of cancer cell growth phenotypes. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 71 mg/mL (199.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 11 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.