CAS No. 2750570-55-7
Batch:
Purity:99.05
Chemical Structure
Check the
BI-0474
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (4S)-2-amino-4-[3-[6-[(2S)-2,4-dimethylpiperazin-1-yl]-4-(4-prop-2-enoylpiperazin-1-yl)-2-pyridinyl]-1,2,4-oxadiazol-5-yl]-4-methyl-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile | |
|---|---|---|
| CAS Number | 2750570-55-7 | |
| Molecular Formula |
C30H37N9O2S |
|
| Molecular Weight (MW) | 587.74 | |
| InChIKey | CKAMBYUZKWQCKJ-ADSBAMQRSA-N |
BI-0474 is a selective covalent inhibitor of mutant KRAS G12C that binds reversibly to the switch II pocket before covalent bond formation. By inhibiting GDP-bound KRAS protein interactions and blocking downstream MAPK pathway signaling, BI-0474 effectively suppresses cancer cell proliferation and exhibits robust in vivo antitumor activity in mutant KRAS G12C tumor models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(170.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.