CAS No. 2776175-74-5
Batch:
Purity:98.65
Chemical Structure
Check the
BHV-2100
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 2776175-74-5 | |
|---|---|---|
| Molecular Formula |
C18H19N3O5S |
|
| Molecular Weight (MW) | 389.43 |
BHV-2100 is a potent, selective, peripherally restricted, and orally available transient receptor potential melastatin 3 (TRPM3) antagonist. By selectively inhibiting TRPM3 channel function, BHV-2100 suppresses calcium influx and downstream nociceptive signaling pathways in peripheral sensory neurons. Consequently, this targeted antagonism reduces pain signaling in preclinical models while avoiding unwanted thermoregulatory changes or sedative effects. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
78 mg/mL
(200.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.