CAS No. 56632-39-4
Batch:
Purity:97.76
Chemical Structure
Check the
BHPI
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3,3-bis(4-hydroxyphenyl)-7-methyl-1H-indol-2-one | |
|---|---|---|
| CAS Number | 56632-39-4 | |
| Molecular Formula |
C21H17NO3 |
|
| Molecular Weight (MW) | 331.37 | |
| InChIKey | FABLAHMQSQFDHR-UHFFFAOYSA-N |
BHPI is a potent noncompetitive inhibitor of estrogen receptor α (ERα). It disrupts protective estrogen–ERα signaling, leading to sustained hyperactivation of the unfolded protein response (UPR) and lethal intracellular calcium depletion. This pathway dysregulation effectively inhibits the proliferation of drug-resistant ERα-positive breast and ovarian cancer cells and induces significant tumor regression in animal xenograft models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
66 mg/mL
(199.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 66 mg/mL |
| Water | Insoluble |
| DMSO |
66 mg/mL
(199.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 22 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.