CAS No. 2283349-24-4
Batch:
Purity:99.00
Chemical Structure
Check the
BGB-8035
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (7S)-2-(3,5-dimethoxy-4-methylphenyl)-7-(1-prop-2-enoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide | |
|---|---|---|
| CAS Number | 2283349-24-4 | |
| Molecular Formula |
C24H31N5O4 |
|
| Molecular Weight (MW) | 453.53 | |
| InChIKey | ZFDGMDVYMNWICG-KRWDZBQOSA-N |
BGB-8035 is an orally active, highly selective covalent inhibitor of Bruton's tyrosine kinase (BTK). By binding to the ATP-binding pocket of BTK, it blocks B-cell receptor (BCR) signaling and Fc receptor (FcRs) downstream pathways. Inhibition of BTK suppresses malignant B-cell proliferation and attenuates autoimmune inflammatory responses, demonstrating significant antitumor and anti-arthritis efficacy in preclinical models of B-cell malignancies and autoimmune diseases. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
91 mg/mL
(200.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.