CAS No. 1446090-79-4
Batch:
Purity:99.73
Chemical Structure
Check the
Lifirafenib (BGB-283)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-[[(1R,1aS,6bR)-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one | |
|---|---|---|
| CAS Number | 1446090-79-4 | |
| Molecular Formula |
C25H17F3N4O3 |
|
| Molecular Weight (MW) | 478.42 | |
| SMILES | C1CC(=O)NC2=NC=CC(=C21)OC3=CC4=C(C=C3)OC5C4C5C6=NC7=C(N6)C=C(C=C7)C(F)(F)F | |
| InChIKey | NGFFVZQXSRKHBM-FKBYEOEOSA-N |
Lifirafenib (BGB-283) is a dual RAF kinase and EGFR inhibitor, displaying activity against recombinant BRAF V600E kinase domain, EGFR, and mutant EGFR T790M/L858R. By targeting both RAF dimer complexes and EGFR signaling, lifirafenib potently blocks downstream MAPK/ERK pathway activation, suppressing cell proliferation and driving tumor regression in BRAF- and EGFR-mutant cancer models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
95 mg/mL
(198.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 95 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Lifirafenib (BGB-283) Clinical Trials
- Lifirafenib (BGB-283) Solubility in DMSO
- Lifirafenib (BGB-283) Stock Solution
- Lifirafenib (BGB-283) Storage
- Lifirafenib (BGB-283) Stability
- Lifirafenib (BGB-283) Molecular Weight
- Lifirafenib (BGB-283) SMILES
- Lifirafenib (BGB-283) Chemical Structure (2D and 3D)
- Lifirafenib (BGB-283) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.