CAS No. 1616385-51-3
Batch:
Purity:99.33
Chemical Structure
Check the
Bezuclastinib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4,5-dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-3-carboxamide | |
|---|---|---|
| CAS Number | 1616385-51-3 | |
| Molecular Formula |
C19H17N5O |
|
| Molecular Weight (MW) | 331.37 | |
| InChIKey | NVSHVYGIYPBTEZ-UHFFFAOYSA-N |
Bezuclastinib is a potent tyrosine kinase inhibitor targeting primary and secondary mutations in c-KIT, including c-KIT D816V. In mutant cell lines and patient-derived models, bezuclastinib inhibits KIT phosphorylation and suppresses downstream MAPK signaling cascade activation. Disruption of these oncogenic pathways inhibits cell proliferation and drives significant tumor regression in tyrosine kinase inhibitor-resistant gastrointestinal stromal tumor models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
33 mg/mL
(99.58 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.