CAS No. 2376257-44-0

Batch: Purity:99.40
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Bexotegrast (PLN-74809) Chemical Structure
Chemical Structure
Check the Bexotegrast (PLN-74809) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S)-4-[2-methoxyethyl-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]-2-(quinazolin-4-ylamino)butanoic acid
CAS Number 2376257-44-0
Molecular Formula

C27H36N6O3
Molecular Weight (MW) 492.61
InChIKey CWOFQJBATWQSHL-DEOSSOPVSA-N

Ordering Information

Biological Activity

Bexotegrast (PLN-74809) is a potent dual selective inhibitor of αvβ6 and αvβ1 integrins. By blocking integrin-mediated activation of TGF-β, it decreases Smad3 phosphorylation, suppresses type I collagen gene expression, and reduces pulmonary collagen deposition in fibrotic lung tissue. Furthermore, targeted inhibition of αvβ6 and αvβ1 integrins downregulates the FAK/Src/Akt/β-catenin signaling pathway to attenuate renal tissue fibrogenesis. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 99 mg/mL (200.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 99 mg/mL
Ethanol 99 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.