CAS No. 174022-42-5

Batch: Purity:99.88
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Bevirimat Chemical Structure
Chemical Structure
Check the Bevirimat product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-(3-carboxy-3-methylbutanoyl)oxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid
CAS Number 174022-42-5
Molecular Formula

C36H56O6
Molecular Weight (MW) 584.83
SMILES CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)OC(=O)CC(C)(C)C(=O)O)C)C(=O)O
InChIKey YJEJKUQEXFSVCJ-WRFMNRASSA-N

Ordering Information

Biological Activity

Bevirimat (PA-457) is a first-in-class HIV-1 maturation inhibitor that targets the Gag polyprotein. It specifically blocks the processing cleavage step at the junction between capsid protein CA and spacer peptide SP1 (CA-SP1) mediated by viral protease. This inhibition disrupts proper viral core condensation and capsid assembly, ultimately leading to the release of immature, non-infectious viral particles and suppressing HIV-1 replication.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (170.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.