CAS No. 472-15-1

Batch: Purity:99.88
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Betulinic acid Chemical Structure
Chemical Structure
Check the Betulinic acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid
CAS Number 472-15-1
Molecular Formula

C30H48O3
Molecular Weight (MW) 456.7
InChIKey QGJZLNKBHJESQX-FZFNOLFKSA-N

Ordering Information

Biological Activity

Betulinic acid is a natural pentacyclic triterpenoid that functions as an inhibitor of NF-κB signaling and HIV-1 replication. It suppresses NF-κB activation induced by diverse inflammatory agents, leading to the downregulation of downstream anti-apoptotic gene products. By modulating mitochondrial membrane potential and activating apoptotic pathways, betulinic acid selectively suppresses tumor cell growth and induces apoptosis in cancer models, including melanoma. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 20 mg/mL (43.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 10 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.