CAS No. 936539-80-9
Batch:
Purity:99.86
Chemical Structure
Check the
Betrixaban maleate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (Z)-but-2-enedioic acid;N-(5-chloro-2-pyridinyl)-2-[[4-(N,N-dimethylcarbamimidoyl)benzoyl]amino]-5-methoxybenzamide | |
|---|---|---|
| CAS Number | 936539-80-9 | |
| Molecular Formula |
C23H22ClN5O3.C4H4O4 |
|
| Molecular Weight (MW) | 567.98 | |
| SMILES | CN(C)C(=N)C1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)OC)C(=O)NC3=NC=C(C=C3)Cl.C(=CC(=O)O)C(=O)O | |
| InChIKey | DTSJEZCXVWQKCL-BTJKTKAUSA-N |
Biological Activity
Betrixaban maleate is a potent, direct factor Xa inhibitor within the blood coagulation system. By selectively binding and inhibiting factor Xa, it disrupts the assembly and catalytic activity of the prothrombinase complex. This inhibition suppresses the conversion of prothrombin into thrombin, ultimately blocking downstream thrombin generation and fibrin clot formation within the thrombotic pathway.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(176.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 1 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.