CAS No. 151-73-5

Batch: Purity:98.23
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Betamethasone sodium phosphate Chemical Structure
Chemical Structure
Check the Betamethasone sodium phosphate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 151-73-5
Molecular Formula

C22H28FO8P.2Na
Molecular Weight (MW) 516.4
SMILES [Na+].[Na+].CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO[P]([O-])([O-])=O

Ordering Information

Biological Activity

Betamethasone sodium phosphate is a synthetic glucocorticoid receptor agonist exhibiting potent anti-inflammatory and immunosuppressive properties. Upon binding to the glucocorticoid receptor, it regulates downstream gene expression and modulates key intracellular signaling pathways, including the NF-κB and PI3K/Akt cascades. This activation inhibits the release of pro-inflammatory mediators and suppresses leukocyte infiltration, resulting in attenuated cellular inflammatory responses. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (193.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.