CAS No. 1743-60-8

Batch: Purity:97
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β-Estradiol 17-Acetate Chemical Structure
Chemical Structure
Check the β-Estradiol 17-Acetate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1743-60-8
Molecular Formula

C20H26O3
Molecular Weight (MW) 314.42
SMILES CC(=O)OC1CCC2C1(CCC3C2CCC4=C3C=CC(=C4)O)C

Biological Activity

β-Estradiol 17-Acetate is a metabolite of estradiol that functions as an estrogen steroid hormone derivative. It interacts with estrogen receptors (ERα and ERβ) to modulate estrogen receptor-mediated transcriptional activation and downstream gene expression. Through engagement of nuclear estrogen receptor pathways, it influences cellular signaling cascades involved in cell proliferation, differentiation, and tissue homeostasis in estrogen-responsive biological systems. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 62 mg/mL (197.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Heldring N, et al. Physiol Rev. 2007;87(3):905-31.

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Note: Technical data last updated: Sep 1, 2026.