CAS No. 65391-42-6
Batch:
Purity:99.87
Chemical Structure
Check the
Bestatin hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid;hydrochloride | |
|---|---|---|
| CAS Number | 65391-42-6 | |
| Molecular Formula |
C16H24N2O4.ClH |
|
| Molecular Weight (MW) | 344.83 | |
| InChIKey | XGDFITZJGKUSDK-UDYGKFQRSA-N |
Bestatin hydrochloride is an aminopeptidase N (APN/CD13) and enkephalinase inhibitor that also suppresses dipeptidyl peptidase-IV (DPP-IV) activity. By inhibiting cell-surface aminopeptidases, it elevates endogenous peptides including angiotensins II and III, decreases cell viability, and induces DNA fragmentation. These actions suppress extracellular matrix degradation and cell invasion, supporting its therapeutic potential in hyperproliferative and inflammatory skin disorders. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
87 mg/mL
(252.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 87 mg/mL |
| Ethanol | 21 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.