Cell-free Assays (IC50/Ki) for Berzosertib (VE-822)
| Key Target | IC50 (Cell-free) | Description | Reference |
|---|---|---|---|
| ATR | 19 nM | Inhibition assay | Download PDF |
Cell-based Assay (IC50) for Berzosertib (VE-822)
| Cell Type | IC50 (Cell-based) | Description | Reference |
|---|---|---|---|
| SW480 cells | 1.245 μM | MTT assay | Download PDF |
| Vero E6 cells | < 25 nM | Secondary screen, IFA to quantify viral-infected cells. | Download PDF |
| Calu-3 cells | 0.48 mM | Supernatants collected and titrated on Vero E6 cells to determine viral titers and IC50 values. | Download PDF |
| HT29 cells (for ATR inhibition) | 19 nM | Not specified beyond "ATR inhibition". | Download PDF |
| human primary lung cells | 0.04 mM | Not specified in this sentence, but likely similar to the ALI culture method (immunofluorescence, viral titer). | Download PDF |
| NT-38 | 249.7 nM | MTT assay | Download PDF |
| NT-32 | 8.8 µM | MTT assay | Download PDF |
| NT-3 | 1.21 µM | MTT assay | Download PDF |
| NT-18LM | 338.2 nM | MTT assay | Download PDF |
Check the
Berzosertib (VE-822)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
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- Berzosertib (VE-822) Mechanism of Action: ATR Inhibition in Small Cell Lung Cancer Cell Research
- Berzosertib (VE-822) Clinical Trials
- Berzosertib (VE-822) Working Concentration | Cell Culture | Treatment
- Berzosertib (VE-822) Solubility in DMSO
- Berzosertib (VE-822) Stock Solution
- Berzosertib (VE-822) Storage
- Berzosertib (VE-822) Stability
- Berzosertib (VE-822) Combination Database
- Berzosertib (VE-822) Molecular Weight
- Berzosertib (VE-822) SMILES
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- Berzosertib (VE-822) Chemical Structure (2D and 3D)
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