CAS No. 486-60-2

Batch: Purity:99.83
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Bergaptol Chemical Structure
Chemical Structure
Check the Bergaptol product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-hydroxyfuro[3,2-g]chromen-7-one
CAS Number 486-60-2
Molecular Formula

C11H6O4
Molecular Weight (MW) 202.16
SMILES C1=CC(=O)OC2=CC3=C(C=CO3)C(=C21)O
InChIKey GIJHDGJRTUSBJR-UHFFFAOYSA-N

Biological Activity

Bergaptol is a natural furanocoumarin isolated from citrus essential oils that acts as a potent inhibitor of cytochrome P450 3A4 (CYP3A4). By inhibiting CYP3A4 catalytic activity, it suppresses the oxidative debenzylation and metabolism of enzymatic substrates. This targeted modulation affects hepatic xenobiotic biotransformation and downstream drug clearance pathways, thereby altering substrate bioavailability and cellular metabolic responses.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 30 mg/mL (148.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 2 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.