CAS No. 478-61-5

Batch: Purity:99.46
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Berbamine Chemical Structure
Chemical Structure
Check the Berbamine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1S,14R)-20,21,25-trimethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaen-9-ol
CAS Number 478-61-5
Molecular Formula

C37H40N2O6
Molecular Weight (MW) 608.72
SMILES CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC
InChIKey DFOCUWZXJBAUSQ-URLMMPGGSA-N

Ordering Information

Biological Activity

Berbamine is a natural alkaloid and Bcr/Abl fusion gene inhibitor that targets Ca2+/calmodulin-dependent protein kinase II (CaMKII) and suppresses NF-kB pathway activation. By targeting CaMKII signaling, berbamine disrupts downstream oncogenic survival cascades and downregulates anti-apoptotic proteins. These molecular actions suppress cell proliferation and potently induce apoptosis across multiple hematologic malignancies, including human leukemia and myeloma cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (164.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.