CAS No. 125602-71-3

Batch: Purity:99.32
Check CoA
Bepotastine Chemical Structure
Chemical Structure
Check the Bepotastine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 125602-71-3
Molecular Formula

C21H25ClN2O3
Molecular Weight (MW) 388.89
SMILES C1CN(CCC1OC(C2=CC=C(C=C2)Cl)C3=CC=CC=N3)CCCC(=O)O

Biological Activity

Bepotastine is a non-sedating, selective antagonist of the histamine H1 receptor. By blocking H1 receptor-mediated signaling pathways, it prevents histamine-induced increases in vascular permeability, eosinophil infiltration, and inflammatory mediator release. This targeted receptor inhibition suppresses allergic inflammatory cascades and significantly attenuates histamine-driven responses, including pruritus, vascular leakage, and allergic skin reactions in preclinical disease models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 78 mg/mL (200.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 78 mg/mL
Ethanol 78 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Can. J. Physiol. Pharmacol. 1997;75(12):C-1-C-10.

Jump to

Note: Technical data last updated: Sep 1, 2026.