CAS No. 3818-50-6

Batch: Purity:99.94
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Bephenium Hydroxynaphthoate Chemical Structure
Chemical Structure
Check the Bephenium Hydroxynaphthoate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 3818-50-6
Molecular Formula

C28H29NO4
Molecular Weight (MW) 443.53
SMILES C[N+](C)(CCOC1=CC=CC=C1)CC2=CC=CC=C2.C1=CC=C2C=C(C(=CC2=C1)C(=O)O)[O-]

Ordering Information

Biological Activity

Bephenium hydroxynaphthoate is an anthelmintic agent and selective activator of nematode B-type nicotinic acetylcholine receptors (AChR), including the Hco-L-AChR1 subtype composed of Hco-UNC-29.1, Hco-UNC-38, Hco-UNC-63, and Hco-ACR-8 subunits. Activation of these receptor complexes induces cation channel opening and membrane depolarization in parasite neuromuscular junctions. This continuous excitation disrupts cholinergic signaling pathways, leading to spastic paralysis and detachment of parasitic nematodes.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 88 mg/mL (198.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.