CAS No. 63238-67-5
Batch:
Purity:98.94
Chemical Structure
Check the
Benzoylmesaconine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 63238-67-5 | |
|---|---|---|
| Molecular Formula |
C31H43NO10 |
|
| Molecular Weight (MW) | 589.67 |
Biological Activity
Benzoylmesaconine is an Aconitum monoester alkaloid exhibiting potent anti-inflammatory and analgesic activities. It suppresses lipopolysaccharide-induced NF-κB and MAPK signaling pathways, leading to down-regulated phosphorylation of IκBα, JNK, p38, and ERK and decreased production of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β. Furthermore, benzoylmesaconine blocks intracellular K+ efflux and disrupts NLRP3 inflammasome assembly, thereby inhibiting IL-1β secretion and GSDMD-N protein expression. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(169.58 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.