CAS No. 23239-88-5

Batch: Purity:99.46
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Benzocaine hydrochloride Chemical Structure
Chemical Structure
Check the Benzocaine hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name ethyl 4-aminobenzoate;hydrochloride
CAS Number 23239-88-5
Molecular Formula

C9H11NO2.HCl
Molecular Weight (MW) 201.65
SMILES CCOC(=O)C1=CC=C(C=C1)N.Cl
InChIKey JAADDQHUJDUAKW-UHFFFAOYSA-N

Biological Activity

Benzocaine hydrochloride is a local surface anesthetic that acts as a blocker of voltage-gated sodium channels. By inhibiting sodium ion influx across neuronal cell membranes, it suppresses action potential generation and propagation along peripheral nerve fibers. This blockade interrupts the transmission of impulses at nerve endings, resulting in diminished neuronal excitability and loss of sensory signaling. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 40 mg/mL (198.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 40 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Ragsdale DS, et al. Science. 1994;265(5179):1724-8.

[2] Butterworth JF 4th, et al. Anesthesiology. 1990;72(6):962-5.

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Note: Technical data last updated: Sep 1, 2026.