CAS No. 50-32-8

Batch: Purity:99.69
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Benzo[a]pyrene Chemical Structure
Chemical Structure
Check the Benzo[a]pyrene product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 50-32-8
Molecular Formula

C20H12
Molecular Weight (MW) 252.31

Ordering Information

Biological Activity

Benzo[a]pyrene is a polycyclic aromatic hydrocarbon carcinogen and agonist of the aryl hydrocarbon receptor (AhR). AhR activation upregulates CYP1A1 gene expression and activates the Src/ERK signaling axis, leading to xenobiotic metabolic bioactivation. These metabolic processes induce stable DNA adduct formation, reactive oxygen species production, and cellular toxicity, ultimately driving chemical carcinogenesis and tumor initiation in animal models.[1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 25 mg/mL (99.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.