CAS No. 3562-84-3

Batch: Purity:99.83
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Benzbromarone Chemical Structure
Chemical Structure
Check the Benzbromarone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 3562-84-3
Molecular Formula

C17H12Br2O3
Molecular Weight (MW) 424.08
SMILES CCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)Br)O)Br

Ordering Information

Biological Activity

Benzbromarone is a cytochrome P450 2C9 (CYP2C9) inhibitor that binds the enzyme with a Ki of 19.3 nM. By potently inhibiting CYP2C9 activity within hepatic xenobiotic metabolism pathways, benzbromarone suppresses the oxidative biotransformation of target drug substrates. This inhibition leads to reduced oxidative clearance, elevated systemic exposure of co-administered therapeutics, and altered pharmacokinetics in biological systems. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
1 mg 5 mg 10 mg
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 85 mg/mL (200.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 15 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.