CAS No. 20187-55-7
Batch:
Purity:99.82
Chemical Structure
Check the
Bendazac
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(1-benzylindazol-3-yl)oxyacetic acid | |
|---|---|---|
| CAS Number | 20187-55-7 | |
| Molecular Formula |
C16H14N2O3 |
|
| Molecular Weight (MW) | 282.29 | |
| SMILES | C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)OCC(=O)O | |
| InChIKey | BYFMCKSPFYVMOU-UHFFFAOYSA-N |
Bendazac (AF-983) is a non-steroidal anti-inflammatory agent that acts as an inhibitor of protein denaturation. By stabilizing native protein structures, it prevents heat- and chemical-induced aggregation of soluble proteins, particularly within lens tissue. This antidenaturant activity suppresses protein cross-linking and insoluble complex formation, thereby attenuating cataractogenic processes and maintaining lens clarity.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
56 mg/mL
(198.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 56 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.