CAS No. 16506-27-7
Batch:
Purity:99.51
Chemical Structure
Check the
Bendamustine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 16506-27-7 | |
|---|---|---|
| Molecular Formula |
C16H21Cl2N3O2
|
|
| Molecular Weight (MW) | 358.26 | |
| SMILES | CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O |
Bendamustine is a nitrogen mustard alkylating agent that induces DNA intra-strand and inter-strand crosslinks. By causing persistent DNA double-strand breaks, it activates DNA damage response signaling pathways, triggering both p53-dependent and p53-independent apoptosis. Furthermore, it downregulates mitotic checkpoints and impairs DNA repair mechanisms, leading to cell cycle arrest and pronounced cytotoxicity in hematologic malignancy cell models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
72 mg/mL
(200.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 7 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.