CAS No. 57-37-4

Batch: Purity:99.69
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Benactyzine hydrochloride Chemical Structure
Chemical Structure
Check the Benactyzine hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 57-37-4
Molecular Formula

C20H25NO3.HCl
Molecular Weight (MW) 363.88
SMILES CCN(CC)CCOC(=O)C(C1=CC=CC=C1)(C2=CC=CC=C2)O.Cl

Biological Activity

Benactyzine hydrochloride is a centrally acting muscarinic acetylcholine receptor antagonist. It selectively blocks cholinergic signaling mediated by muscarinic acetylcholine receptors within the central nervous system. By inhibiting muscarinic receptor activation, this compound attenuates downstream cholinergic neurotransmission, modulating neuronal excitability, synaptic plasticity, and behavioral phenotypes involved in central nervous system function and affective regulation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 72 mg/mL (197.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 72 mg/mL
Ethanol 72 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Caulfield MP, et al. Pharmacol Rev. 1998;50(2):279-90.

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Note: Technical data last updated: Sep 1, 2026.